The most popular fabric for throw blankets is microfiber. This is a great option if you’re looking for something incredibly soft, and also something that resists fading better than cotton does. Additionally, microfiber is more elastic and thus doesn’t bunch over time the way cotton does. Not to mention it is also wrinkle-resistant. But if microfiber isn’t your style, you can also choose from cotton, wool, down, fleece, cashmere and more. The fabric really comes down to personal preference.